I have a 2010 f150 super crew.For the past couple of months it has a noise that sounds like i'm running over the cut out strips on the outside of most roads to let you know you are about to run off the road.It seems to do it more going up a hill and traveling around 50 or55 mph.I thought it was the road that I travel daily to and from work because it does it at about the same place every time.I have tried to make it do it every way I can,but nothing I do makes it any worse or any better.It sounds like its metal to metal but I don't know.Anyone else had this problem?

 

Could be torque shudder. Have the transmission fluid changed and see if that helps.