Found my old records. Thought it was interesting.

2005 Supercab XLT 4x2 5.4L 3.55
300 bhp / 365 Torq
14.5 mpg Lifetime

2015 Supercab XL Sport 4x4 2.7EB 3.55
325 bhp / 375 Torq
22.1 mpg Lifetime

So I went from 2wd to 4wd and still gained over 50% in fuel mileage.

 

Interesting, on my 2005 F-150 Lariat Supercrew 4x4 3.55 I started tracking mpg late into my ownership (using Fuelio)
400 gallons
15.7 avg
17.5 best (trip from Atlanta to Texas)
14.4 worst

Back/forth to work, I'd average about 15.3

I got a 2019 Supercab XLT Sport 4x2 5..0 3.55
20.5 avg, I have less than 3,000 miles on it