Thewho64

I have a 06 lariat 5.4 automatic 183,000 miles. Giving multiple codes. Cam sensor\ intermittent, bank a running lean, and every once in a while it gives a multpile misfire code(cylinders vary each time.) at first had a stumble in overdrive at 45-50 miles and hour. Now it doesn't seem to go above 2nd gear in overdrive. Truck seems to run ok when not in overdrive. Any ideas wear to start? Previous owner replaced both cam sensors, all plugs and coils? Could the misfires be causing the trans problems ?