If it was me and I was starting from scratch I would go with an F250/F350 with 8 foot bed and get a full size slide in camper...11 or 12 footer. I would get a extended reciever bar and hook the boat on that. My dad did that with his and went for 4 months from STL to the far reaches of Northern Alaska, BC and the Yukon, twice, over 14,000 miles. He never had a problem and could launch into many of the streams/rivers in North America.
'11 F150 XLT Red Candy Met. Ecoboost 4X4 Screw 5.5' Max Tow, Reese R16k 5th wheel hitch, Firestone air bags, Extang Full-Tilt Cover Michelin LTX AT2 "E" rated 20s.
'13 Keystone Cougar XLite 29RES, triple slides, Mor/ryde suspension, Reese 5th Airborne Sidewinder pin box coupler, 16" rims w/ "E" rated STs.