Yes. Be sure to remove the SPOUT connector before setting, and to re-insert upon completion. This is what looks like a dummy plug in a connector near the distributor. Other than that, pretty typical procedure using a timing light and rotating the distributor.
As far as what to set to - the handy-dandy Chilton's manual refers one to the underhood sticker. Not sure what the 4.9L's get, the 5.0L's get 10BTDC.